Adobe Photoshop for image tweakage of all kinds and fun programmatic manipulations of images via JavaScript, iView Media Pro for managing collections of images, rdiff-backup for backing up and keeping revisions of files or directories over the network, Chicken of the VNC for remote management of other machines (particularly Windows machines where you need a GUI or can’t get a shell via ssh), Disk Inventory X for figuring out where my disk space went, Neo Office for when I need to use Office-ish documents — it’s so compatible with MS Office that it has most of the same annoyances, Passwords Plus to manage passwords (and synch them to my Treo), Snail Mail to print envelopes, Audacity for editing sounds (remember SoundEdit16 from the old days?), Google Earth for wasting enormous amounts of time, and Study Card Studio for learning Spanish.

(Also, stuff for development like MAMP for the PHP/MySQL/Apache instance that’s easy to manage, YourSQL a decent database tool for MySQL when you don’t want to use the command line, and, of course, the universe of Ruby on Rails for when you want to be all Web 2.0 and stuff.